Quicklinks: Job Postings
Small Molecule Makes Heart Cells Out of Stem
San Diego, Calif., November 14, 2012 –
Researchers at the Human BioMolecular Research
Institute, Sanford-Burnham Medical Research Institute
(Sanford-Burnham), and ChemRegen, Inc. have created a
small molecule that convert stem cells to heart cells.
Writing November 6th in the Journal of Medicinal
Chemistry, the team describes how they synthesized and
tested ITD-1, a man-made, drug-like chemical that can
be used to generate unlimited numbers of new heart
cells from stem cells.
“Because heart disease is the leading cause of death
in this country, we need to effectively replace lost
heart muscle cells—called cardiomyocytes,” said Mark
Mercola, Ph.D., director of Sanford-Burnham’s Muscle
Development and Regeneration Program and co-author of
the study. “Using a small molecule to create new heart
muscle cells from stem cells is very appealing.”
CLICK HERE to read the full
HERE to read more about the exciting work being
done by HBRI scientists.
Human BioMolecular Research Institute (HBRI) is a
501(c)3 tax-exempt non-profit research institute doing
basic research for the public good. HBRI was founded
in December of 1997.The institute is located in the heart of
biotech beach in a state-of-the-art 6,700 sq. ft.
The research programs at HBRI are focused on
unlocking biological and chemical principles related
to diseases of the human brain.
Included in the areas of study are:
Alzheimer’s disease and related neurodegenerative
disorders, Parkinson’s disease, ALS, depression,
neuroprotection, regenerative medicine, cardiovascular
disease, cancer, drug and alcohol abuse, pain and
The institute conducts fundamental studies of
central nervous system disorders and translates
findings into new drug development to address human
addition, the institute promotes scientific learning
through community service and public access by
disseminating information and sharing research with
collaborators, colleagues and the public.
Brain is not the Same"